Introduction
A version of this essay was submitted as a comment on Feb 8, 2025 to Kulldorff, M. 2025 The rise and fall of scientific journals and a way forward. Journal of the Academy of Public Health, 1, doi: 10.70542/rcj-japh-art-45qyn0
This version corrects a couple of minor typographical errors in the submitted version, and is in other ways slightly edited. The figures are added, as are the hyperlinks and some additional details (most changes shown in red). Some of the links may not work properly. I will try to fix them when I have more time. I also may add to this essay.
Some highlights are in pink. The text in pink is in the text of my submitted comment.
**
Thank you. This journal and this article are greatly needed, to partially redress the bias of so many conflicted "legacy" journals.
You state: The Lancet published "the now infamous paper claiming that the Covid lab leak hypothesis was a racist conspiracy theory." The 324 word letter that you cite [1] (Calisher et al) was published when very little was known about the origin of SARS-CoV-2, the virus that caused the Covid-19 pandemic.
This letter, published online on February 18, 2020 (date of submission unstated, but no earlier than February 7, 2020) warrants opprobrium. It can be interpreted as characterising scientists with an alternative pandemic origin hypothesis as exclusively conspiracists, by stating: “We stand together to strongly condemn conspiracy theories suggesting that COVID-19 does not have a natural origin”. These words, which are not qualified elsewhere in the letter, imply that the authors of Calisher et al thought there could be no legitimate scientific reason for a non-natural origin to the pandemic. This wording also appears disingenuous, since three of the authors of Calisher et al were centrally involved with the global virome project, [2] which had previously warned that the threat of “lab-enhanced viruses” was “intensifying”, due to both “gain of function” experiments and to “do it yourself” research. [3] (See images below - source: slides 2 and 4 in ref 3, originally published in 2017.)
The expressed certainty of Calisher et al concerning the origin of the SARS-CoV-2 was questionable for another reason. This is that the remarkable and extensive capacity of SARS-CoV-2 for asymptomatic (“stealth”) [4] transmission, whether air-borne or via bodily fluids, strongly distinguished it not only from SARS-CoV-1, but from all “naturally sourced” zoonoses other than influenza and HIV/AIDS (the latter which lacks air-borne transmission). [5] SARS-CoV-1 also lacks asymptomatic transmission capacity, as do viruses such as Ebola, Nipah, Marburg and Lassa. [5] Although asymptomatic transmission Middle East respiratory syndrome (MERS) has been reported [6] the capacity of the causal coronavirus for MERS to sustain transmission at scale is far lower than for SARS-CoV-2, as all MERS outbreaks to date have been quickly sequestered and thus terminated. [5] In contrast, SARS-CoV-2 generated a global pandemic, with an excess mortality (until 2022) of at least 5.9 million, with one authoritative estimate as high as 18.2 million (95% uncertainty interval 17·1–19·6 million). [7] COVID-19 also causes enormous and ongoing morbidity, including from long COVID. [8]
However, in contrast to a claim made in your article, [9] the authors of Calisher et al did not allege that scientists with competing views were racist, though it incorrectly praised “scientists, public health professionals, and medical professionals of China, in particular” as working diligently including to “share their results transparently with the global health community”. While some Chinese health professionals deserve such accolades, Calisher et al failed to mention counter examples, such as Dr Li Wenliang, the ophthalmologist working in Wuhan who, on December 30, 2019, warned a group of his medical colleagues of a possible outbreak of a syndrome like severe acute respiratory syndrome (SARS). Within days, he was summoned by Chinese government authorities and forced to sign a statement in which he was accused of making false statements that disturbed the public order. [10] Subsequent to the publication of Calisher et al the New York Times reported that “thousands of secret government directives and other documents that were reviewed” laid “bare in extraordinary detail the systems that helped the Chinese authorities shape online opinion during the pandemic.” [11]
There is, however, a powerful additional reason for the infamy of Calisher et al. This is the failure of any of its 27 authors to initially acknowledge any conflict of interest. In June 2021 two or more Lancet editors published an addendum [12] which stated that “some readers” had questioned the validity of the non-disclosure of any conflict, particularly as they related to one author, who was later revealed (via emails obtained by U.S. Right to Know) to have covertly organised Calisher et al. [13] In September 2021 a science journalist published a newspaper article [14] claiming (with some details) that 26 of the 27 authors of Calisher et al were linked, to varying degrees, with the Wuhan Institute of Virology, the leading Chinese laboratory for coronavirus research.
One co-author of Calisher et al was appointed in 2012 as a board member [15] for the organisation EcoHealth Alliance, for which the covertly convening author had then been president for several years. This organisation was a major conduit of U.S. funding to the Wuhan Institute of Virology, as reported in 2020. [13] Some of its funding was derived from USAID. Six co-authors of Calisher et al (including said former board member, a very senior scientist) were, in 2020 and for some time after, listed prominently on the EcoHealth Alliance’s website, either as members of the board (three) or having roles with the related journal EcoHealth (four). The president of the EcoHealth Alliance was also the chief editor of EcoHealth, and is here counted twice.
Links between the EcoHealth Alliance (or the journal EcoHealth) are only mentioned in the authorial details of one contributor to Calisher et al. As at February 8, 2025 all six with conflicts related to the EcoHealth Alliance remain visible either on the website of the EcoHealth Alliance (two as “adjuncts”), [16] or the editorial board of the related journal EcoHealth (five). [17] One is listed in each category, however none are now listed as board members of the EcoHealth Alliance [18] though at least three were as of March 2023. Several of the other authors of Calisher et al also had apparent (and also still undeclared) conflicts of interest, including a scientist who then headed the Wellcome Trust, and who is now the chief scientist for the World Health Organization (WHO). [19]
The initial failure of any of the 27 authors of Calisher et al to declare a single conflict of interest was quickly perceived by many. This observation was also relayed, in 2020, to Lancet editor in chief, Richard Horton, who in December 2021 publicly acknowledged that “it took over a year” to persuade the letter’s co-ordinator that he needed to declare his conflict of interest. [20]
Calisher et al repeatedly laud the value of “transparency”. They are far from alone. For example, a paper whose final (senior) co-author is a scientist who has long studied viral manipulation published an article concluding “rapid, transparent communication is paramount when infectious diseases emerge. This is the only way to prevent major outbreaks and will save many lives.” [21] However, transparency is inconsistent not only with the failure by the authors of Calisher et al to initially declare any conflict of interest, but also with the stated risk, previously highlighted by the global virome project, of the dangerous potential of laboratory-modified or enhanced pathogen variants. [3]
In response to a request by two or more Lancet editors, a 151 word disclosure of conflicts was belatedly published by the journal on June 21, 2021, in relation to Calisher et al. [12] Yet this disclosure also failed to mention the strong research and funding links between the letter’s organiser and the Wuhan Institute of Virology.
In January 17, 2025 (before President Trump's second term) the scientist who covertly organised the publication of Calisher et al was debarred by the United States Department of Health and Human Services, effective until May 14, 2029. [22] This was done “in order to protect the Federal Government’s business interests.” In the same month, EcoHealth Alliance, the organisation that this scientist once led (by then for approximately 15 years) was also debarred, for the same time, and for the same stated reason. [23]
On January 6, 2021, 14 authors (of whom I am one) submitted an 1185 word article to The Lancet criticising the main thesis of Calisher et al. [24] This was quickly rejected, without review, thus extending the time in which the original, strongly partisan letter (i.e. Calisher et al) was apparently left unchallenged by readers of and contributors to The Lancet. Eventually, however, a 1260 word version of this response (with 16 authors of whom 11 overlapped with the earlier authorial team; again I am one) was published on September 17, 2021. [24] This was submitted on July 15, 2021, and received no external review. Thus, between February 18, 2020 and September 17, 2021 (578 days) readers of The Lancet may have believed that the propositions advanced by Calisher et al were unchallenged by readers and potential contributors to The Lancet. However, over 40% of this period of apparently passive acceptance of Calisher et al was due to an editorial decision of The Lancet. It is also possible that other articles challenging Calisher et al were submitted to The Lancet in this period, but also not accepted for publication.
It is here postulated that the key reason for The Lancet editorial team’s reversal of judgement about publishing articles critical of Calisher et al was that in the period following consideration of the first rejected article [24] (i.e. about January 10, 2021) and soon after submission (July 15, 2021) of the eventually accepted article [25] The Lancet’s editor in chief started to understand the scope of the lack of transparency of the covert lead author of Calisher et al. Also in this period (May 14, 2021), another prestigious legacy journal, Science, published a letter hypothesising that SARS-Co-V-2 may have arisen via laboratory processes. [26] The date of submission of that letter is not stated by Science (as is normal practice for letters to both Science and The Lancet).
On September 14, 2022 a key finding of The Lancet COVID-19 Commission was published, stating that while the “proximal” origin of SARS-CoV-2 remained unknown there were two leading hypotheses. [27] These were that the virus emerged as a zoonotic spillover from wildlife or a farm animal, possibly through a wet market, in a location that is still undetermined; or that the virus emerged from a research-related incident, during the field collection of viruses or through a laboratory-associated escape. This conclusion closely matched the main point of the article that was submitted to The Lancet on January 6, 2021, but rejected within a few days. [24]
Your article [9] discusses the “rise and fall” of scientific journals. You identify The Lancet as a prestigious and prominent legacy journal, and imply that its reputation may now be in decline. The Lancet has an admirable, campaigning origin, [28] but it has previously been on the wrong side of history, not only through the examples you list, but also when its founding editor failed to fully recognise the value of the pioneering ideas of John Snow. [29]
Such errors may be inevitable. However, The Lancet’s mistake concerning the certainty of the origin of SARS-Co-V-2 arose from factors additional to poor scientific judgement. It was also contributed to by the journal’s failure to follow basic scientific process.
In early 2020 it was impossible to know the cause of the pandemic with confidence. The bias of Calisher et al should have been a red flag to the journal’s editorial team, but apparently its strongly expressed views were considered acceptable. However, it would have then been comparatively straightforward to check for obvious conflicts of interest, such as via a quick internet search. Calisher et al (as with the two relevant submissions to The Lancet with which I was involved) apparently received no external review. It also was published with alacrity. Emails obtained by US Right to Know show that, as of February 6, 2020 the authorial team for Calisher et al remained in flux. [13] Thus, time between submission and publication was 12 days or fewer. These emails also show that the lead author intended it to “not be identifiable as coming from any one organization or person” but rather to be seen as “simply a letter from leading scientists”. One email stated: “We'll then put it out in a way that doesn't link it back to our collaboration so we maximize an independent voice”. [30]
A review of Calisher et al, provided it was undertaken by knowledgeable and non-partisan scientists, is likely to have identified some of the most obvious (yet undeclared) conflicts of interest. Notification of this ethical shortfall to The Lancet's editors would almost certainly have also diluted the letter’s expressed certainty, including by preventing it from characterising all scientists with opposing views as “conspiracists”. It is striking that the Lancet’s editorial team, in early 2020, felt sufficiently confident about the knowledge and integrity of the authors of Calisher et al to publish it so quickly, yet lacked the wisdom to then suspect any conflict of interest.
Neither a review nor cursory check for potential conflicts of interest was undertaken. The Lancet's chief editor later advised a British parliamentary committee that the policy of The Lancet (at least in 2020) was to accept conflict of interest declarations at face value. [20] However, the scale and weight of undeclared interests among the many authors of Calisher et al was quickly apparent to many experts, some of whom warned The Lancet’s chief editor. [20] Five years later, the debarring of both the letter’s chief instigator, and of the EcoHealth Alliance is additional evidence of the misjudgement and bias of The Lancet’s editorial board in early 2020, concerning the origin of SARS-Co-V-2. This naïveté still dominated The Lancet editorial board’s decision-making processes in early January 2021, when the lengthy response submitted by van Helden et al [24] was rejected, even though one Lancet editor then appeared somewhat sympathetic to the arguments contained in this.
The authors of this rejected paper were also far less compromised by research links involving viral manipulation in China and elsewhere. If The Lancet editorial team had had a deeper understanding of the marked difference in conflicts of interest between the two authorial teams then the decision to reject the second article may have been avoided.
The Lancet must retract Calisher et al, including because of the severity of the pandemic, and the ongoing debate about biosafety. [31] The influence of Calisher et al (cited 370 times, by Google Scholar, February 8, 2025) has been overwhelmingly malign. Its harm rivals or exceeds that caused by The Lancet’s publication of a later discredited article that suggested that the measles, mumps and rubella vaccine may cause autism. [32] The Lancet took almost 12 years to retract that paper. (The journal had the same chief editor then as now; he was appointed to his current role in 1995.)
The concerns about Calisher et al are magnified by the still ongoing failure of the great majority of this letter’s authors to fully disclose their conflicts of interest. These authors have now had almost five years to make such a declaration. In that time, far more evidence has been uncovered of relevance to the origin of SARS-Co-V-2. [33-34] This additional evidence also undermines the certainty expressed by Calisher et al. The fact that so much evidence has been revealed grudgingly, and through the ingenuity, persistence and effort (including legal) of investigators also belies the assertions by the authors of Calisher et al and others that relevant scientists genuinely place a high value on transparency.
It is also of concern that 99 scientists, some of them very senior, remain affiliated with the journal EcoHealth, despite the scandal surrounding its lead editor and its more recently affiliated organisation, the EcoHealth Alliance. Many of this journal’s editorial board are aware of the alleged lack of integrity of both its chief editor and of this organisation. This is not only through extensive, highly unfavorable publicity, but also because, in 2022, I wrote to almost all of them. [35-36] Although there is one exception that I currently know of [37] it appears that ethical considerations among the EcoHealth advisory board are generally trumped by other factors. This ethical malaise is relevant to the wider problem in scientific publishing and scientific integrity. [38]
Calisher et al must be retracted, and its painful lessons absorbed. This would be an important step in the gargantuan task of partially restoring public trust in scientific integrity. The origin of the pandemic remains uncertain, but the weight of evidence suggests a laboratory origin. If any conspiracy existed, it is documented to have arisen among those who were involved with funding risky work involving coronaviruses in China, some of which was knowingly performed in in laboratories in China, in part funded by the U.S. which used lower standards of biosecurity than would have been legally possible in the U.S., [34] for this work with its long recognised risks. [39]
Declaration
From 2007 to 2013 the author was associated with the journal EcoHealth, as review editor (2007-2010) and then as a co-editor (2010-2013). At that time this journal was not directly linked with the EcoHealth Alliance, but instead with the International Association for Ecology and Health (since renamed as EcoHealth International). The author resigned from this journal in 2013 due to concerns about insufficient scientific integrity. The author has never sought, nor received, funding for work involving the alteration of viruses nor any other genetic material. The author has no research grants associated with China. The author has no affiliation with EcoHealth International, though he did with its predecessor. The author has never had any role with the EcoHealth Alliance.
References
Many are open access (sometimes with free registration). The ones that I am certain are behind a paywall have three stars in this colour, deep green. *** In many cases I have added "open access".
1. Calisher C, Carroll D, Colwell R, Corley RB, Daszak P, Drosten C, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya A, Haagmans B, Hughes JM, Karesh WB, Keusch GT, Kit Lam S, Lubroth J, Mackenzie JS, Madoff L, Mazet J, Palese P, Perlman S, Poon L, Roizman B, Saif L, Subbarao K, Turner M. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19. The Lancet, 395:e42-3, 2020. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30418-9/fulltext
2. Carroll D, Daszak P, Wolfe ND, Gao GF, Morel CM, Morzaria S, Pablos-Méndez A, Tomori O, Mazet JAK. The global virome project. Science, 359, 872–874. https://www.science.org/doi/10.1126/science.aap7463 2018 ***
3. The global virome project. https://www.slideshare.net/SirTemplar/2017-0907-global-virome-project 2017.
4. Butler CD, Infectious disease emergence and global change: thinking systemically in a shrinking world. Infectious Diseases of Poverty, 1, 5. http://www.idpjournal.com/content/1/1/5 2012, open access.
5. United Nations Environment Programme (UNEP). COVID-19: A Warning. Addressing Environmental Threats and the Risk of Future Pandemics in Asia and the Pacific. Bangkok, Thailand. https://wedocs.unep.org/20.500.11822/40871 2022, open access.
In mid-2020 the UNEP commissioned me to research and write this 70 page report, for which I was sole author, other than its one page foreword, written by Dechen Tsering, UNEP's Regional Director and Representative for Asia and the Pacific. (NB not "lead" author, as the report states - see figure below). It had 228 references and was reviewed by 34 people, including 13 from UNEP, three (each of whom was hostile) from universities in China, and two from the French embassy to Viet Nam. I was paid approximately US$20,000 for my work on this (I worked intensively on this for over a year - since mid-2016 I have only had unpaid university appointments. The upside of having no salary is that I can choose my priorities). UNEP also invested financially in this report, such as the involvement of its own staff and a graphic designer. This report was funded by NorAd (Norwegian Aid) (see figure). The report states that I completed the research for it on Feb 3., 2022. However, the changes to the text in 2022 were trivial. Research was actually completed in early December 2021.
After its completion, UNEP not only refused to publish this report, but also stopped communicating with me. Their refusal to publish this report was, in my opinion, due to the fact that it clearly advised that a laboratory origin for the pandemic was plausible. Eventually I was able to communicate with a representative of NorAd, to complain about UNEP's timidity. Within a month of that communication - with no explanation, apology, or fanfare - my report was finally released by UNEP. I documented some of this pathetic story in an article published in January 2023, in the Daily Mail, co-authored with Prof Delia Randolph (nee Grace) who had led the initial report by the UNEP into to the covid-19 pandemic; see "There has been a suppression of the truth, secrecy and cover-ups on an Orwellian scale" at https://www.dailymail.co.uk/news/article-11687597/There-suppression-truth-secrecy-cover-ups-origin-Covid-19-China.html (reference 37 in this essay)
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9. Kulldorff, M. The rise and fall of scientific journals and a way forward. Journal of the Academy of Public Health, 1, https://publichealth.realclearjournals.org/perspectives/2025/01/the-rise-and-fall-of-scientific-journals-and-a-way-forward/ 2025, open access
10. Green A. Li Wenliang. The Lancet, 395, P682, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30382-2/fulltext 2020
11. Zhong, R., Mozur, P., Kao, J. & Krolik, A. No ‘negative’ news: how China censored the coronavirus. The New York Times, https://www.nytimes.com/2020/12/19/technology/china-coronavirus-censorship.html 2020. *** Also see: Hvistendahl, M. & Mueller, B. Chinese censorship is quietly rewriting the covid-19 story. The New York Times https://www.nytimes.com/2023/04/23/world/europe/chinese-censorship-covid.html 2023 ***
12. Editors of The Lancet. Addendum: competing interests and the origins of SARS-CoV-2. The Lancet, 397, 2449-2450, 2021. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01377-5/fulltext
13. Suryanarayanan, S. EcoHealth Alliance orchestrated key scientists’ statement on “natural origin” of SARS-CoV-2. https://usrtk.org/biohazards-blog/ecohealth-alliance-orchestrated-key-scientists-statement-on-natural-origin-of-sars-cov-2/ 2020.
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15. https://www.ecohealthalliance.org/2012/11/ecohealth-alliance-announces-dr-rita-colwells-election-to-board-of-directors
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25. van Helden J, Butler CD, Achaz G, Casane D, Claverie J-M, Colombo F, Courtier V, Canard B, Ebright RH, Graner F, Leitenberg M, Morand S, Segreto R, Petrovski N, Decroly E, Halloy J. An appeal for an objective, open and transparent scientific debate about the origin of SARS-CoV-2. The Lancet, 398, 1402–1404, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext 2021.
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29. Hempel S, John Snow. The Lancet, 381, 1269-1270, 2013.
30. https://usrtk.org/wp-content/uploads/2021/02/Baric_Daszak_email.pdf (accessed 8 Feb, 2025)
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32. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. The Lancet, 351:637-41, 1998. (retracted by the journal, February 17, 2010).
33. DRASTIC “The DARPA DEFUSE Project” https://drasticresearch.org/2021/09/20/1583/ and https://s3.documentcloud.org/documents/21066966/defuse-proposal.pdf 2021.
34. Kopp E. American scientists misled Pentagon on research at the Wuhan Institute of Virology. US Right to Know, https://usrtk.org/covid-19-origins/american-scientists-misled-pentagon-on-wuhan-research/ 2023.
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36. Butler CD. Reflections on my open letter about ethics to the editorial board of the journal EcoHealth https://globalchangemusings.blogspot.com/2022/11/reflections-on-my-open-letter-about.html 2022.
37. Butler CD, Randolph (nee Grace) D. There has been a suppression of the truth, secrecy and cover-ups on an Orwellian scale https://www.dailymail.co.uk/news/article-11687597/There-suppression-truth-secrecy-cover-ups-origin-Covid-19-China.html Daily Mail, 2023.
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